OncoBone founders have a strong scientific background working in oncology and bone diseases. OncoBone offers scientific expertise especially in, but not limited to these fields.
Scientific consulting can include for example
Below you can find some examples of our scientific publications.
Kähkönen TE, Suominen MI, Halleen JM, Bernoulli J 2021 Preclinical Bone Metastasis Models Chapter of a book ‘Animal Models for Development of Cancer Immunotherapy’. In press (Invited book chapter, estimated publication March 2021).
Kähkönen TE, Halleen JM, Bernoulli J 2020 Immunotherapies and metastatic cancers: understanding utility and predictivity of human immune cell engrafted mice in preclinical drug development. Cancers 12(6):1615 (invited review article).
Kähkönen TE, Tuomela JM, Grönroos TJ, Halleen JM, Ivaska KK, Härkönen PL 2018 Dovitinib dilactic acid reduces tumor growth and tumor-induced bone changes in an experimental breast cancer bone growth model. J Bone Oncol 16:100232.
Rissanen JP, Halleen JM 2010 Models and screening assays for drug discovery in osteoporosis. Expert Opin Drug Discov 5:1163-1174 (invited review article).
Rissanen JP, Suominen MI, Peng Z, Morko J, Rasi S, Risteli J, Halleen JM 2008 Short-Term Changes in Serum PINP Predict Long-Term Changes in Trabecular Bone in the Rat Ovariectomy Model. Calcif Tissue Int 82:155-161.
Rissanen JP, Ylipahkala H, Fagerlund KM, Long C, Väänänen HK, Halleen JM 2009 Improved methods for testing antiresorptive compounds in human osteoclast cultures. J Bone Miner Metab 27:105-109.
Nenonen A, Cheng S, Ivaska KK, Alatalo SL, Lehtimäki T, Schmidt-Gayk H, Uusi-Rasi K, Heinonen A, Kannus P, Sievänen H, Vuori I, Väänänen HK, Halleen JM 2005 Serum TRACP 5b Is a Useful Marker for Monitoring Alendronate Treatment: Comparison With Other Markers of Bone Turnover. J Bone Miner Res 20:1804-1812.
Halleen JM, Alatalo SL, Suominen H, Cheng S, Janckila AJ, Väänänen HK 2000 Tartrate-Resistant Acid Phosphatase 5b, a Novel Serum Marker of Bone Resorption. J Bone Miner Res 15:1337-1345.
Halleen J, Hentunen TA, Hellman J, Väänänen HK 1996 Tartrate-Resistant Acid Phosphatase: Purification and Development of an Immunoassay. J Bone Miner Res 11:1444-1452.
From our complete list of publications you can find out more about our contribution to research.
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