Preclinical osteoporosis

Strube A, Suominen MI, Rissanen JP, Mumberg D, Klar U, Halleen JM, Käkönen SM 2011 The anti-tumor agent sagopilone shows antiresorptive effects both in vitro and in vivo. Osteoporos Int 22:2887-2893.

Rissanen JP, Halleen JM 2010 Models and screening assays for drug discovery in osteoporosis. Expert Opin Drug Discov 5:1163-1174 (invited review article).

Rissanen JP, Ylipahkala H, Fagerlund KM, Long C, Väänänen HK, Halleen JM 2009 Improved methods for testing antiresorptive compounds in human osteoclast cultures. J Bone Miner Metab 27:105-109.

Rissanen JP, Suominen MI, Peng Z, Morko J, Rasi S, Risteli J, Halleen JM 2008 Short-Term Changes in Serum PINP Predict Long-Term Changes in Trabecular Bone in the Rat Ovariectomy Model. Calcif Tissue Int 82:155-161.

Rissanen JP, Suominen MI, Peng Z, Halleen JM 2008 Secreted Tartrate-Resistant Acid Phosphatase 5b is a Marker of Osteoclast Number in Human Osteoclast Cultures and the Rat Ovariectomy Model. Calcif Tissue Int 82:108-115.

Narva M, Rissanen J, Halleen J, Vapaatalo H, Väänänen K, Korpela R 2007 Effects of bioactive peptide, valyl-prolyl-proline (VPP), and lactobacillus helveticus fermented milk containing VPP on bone loss in ovariectomized rats. Ann Nutr Metab 51:65-74.

Narva M, Halleen J, Väänänen K, Korpela R 2004 Effects of Lactobacillus helveticus fermented milk on bone cells in vitro. Life Sci 75:1727-1734.

Alatalo SL, Peng Z, Janckila AJ, Kaija H, Vihko P, Väänänen HK, Halleen JM 2003 A novel immunoassay for the determination of tartrate-resistant acid phosphatase 5b from rat serum. J Bone Miner Res 18:134-139.

SurveVV, Andersson N, Alatalo SL, Lehto-Axtelius D, Halleen JM, Väänänen HK, Håkanson R 2001 Does Combined Gastrectomy and Ovariectomy induce greater Osteopenia in Young Female Rats than Gastrectomy alone? Calcif Tissue Int 69:274-280.

Alatalo SL, Halleen JM, Hentunen TA, Mönkkönen J, Väänänen HK 2000 Rapid screening method for osteoclast differentiation in vitro that measures tartrate-resistant acid phosphatase 5b activity secreted into the culture medium. Clin Chem 46:1751-1754.