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iNSiGHT small animal DXA

OncoBone acts as a distributor for small animal Dual-energy X-ray Absorptiometry (DXA) iNSiGHT of OsteoSys in Europe.

iNSiGHT DXA in bone and metabolic research

Dual-energy X-ray Absorptiometry(DXA) is an imaging technology mostly utilized in bone and metabolic research that is based on different absorption of high and low energy X-rays, making it possible to accurately separate soft tissue (fat and lean) and hard tissue (bone), and to perform detailed analysis on bone density and body composition (see Table 1 for more details).

iNSiGHT is one of the market-leader DXA devices used to analyze bone density and body composition in small animals. It is widely used in research in academic institutions and companies globally. Research areas currently benefiting from iNSiGHT include:

  • Metabolic bone diseases (osteoporosis, rare bone diseases, rickets, osteomalacia etc.)
  • Musculoskeletal diseases (osteoarthritis, bone fractures and healing, bone and muscle regeneration, Duchenne muscular dystrophy, sarcopenia, cachexia etc.)
  • Dental (osteonecrosis of the jaw, implant research etc.)
  • Metabolic disorders (metabolic syndrome, disease, obesity etc.)
  • Oncology (osteosarcoma, bone metastasis, multiple myeloma bone disease, cancer-induced osteolysis, treatment-induced osteolysis etc.)
  • Other areas (preclinical efficacy and safety studies, morphological and longitudinal follow up of phenotype development in for example transgenic mice)

Read also our Blog post for examples on how researchers have utilized iNSiGHT in their studies.

Table 1: Measurement readouts in iNSiGHT

BMCgBone Mineral Content (Bone Mass) = bone density x bone area
FATgFat Mass
FAT%Fat ratio = Fat mass / Total mass
LEANgFat free mass
Total MassgTotal mass = Fat + Lean + Bone mass
BMDg/cm2Bone Mineral Density
Bone Areacm2Bone Area in Image
Tissue Areacm2Tissue Area in Image

Advantages of iNSiGHT DXA in bone and metabolic research

See the following video for demonstration of iNSiGHT DXA

General advantages of DXA technology over other standard imaging techniques used in bone and metabolic research include:

  • Whole-body imaging capability
  • Analysis of whole-body images and user defined Regions of Interest (ROIs)
  • Longitudinal imaging with inhalation anesthesia supported
  • Analyzing changes in whole-body or ROIs at any time point during or after the study
  • Rapid imaging and analysis of results that allows making decisions during the study
  • Imaging and analysis of ex vivo samples
  • Low dose radiation allowing repeated measurements safely in small animals

Advantages of iNSiGHT over other DXA devices in the market:

  • Faster imaging and analysis
  • Higher precision and accuracy
  • Suitable for animals weighing from 10 to 1 000 grams
  • Analysis program included in the purchase
  • Easy-to-use device and software
  • Cost-effective
  • Training and support available

Table 2: iNSiGHT specifications

X-ray SystemDXA (Dual-Energy X-ray Absorptiometry)
Scan MethodCone Beam
Scan ObjectSmall Animals (10~1000 g)
Scan Time25 sec. (10 sec. for X- ray exposure + Measurement)
Measurement ParameterBMD (g/cm²), BMC (g), Bone Area (cm²), Tissue Area (cm²) Fat ratio (%), Fat mass (g), Lean mass (g), Total Weight (g)
PrecisionCV < 1%
AccuracyR² > 0.9
Image area16.5 cm x 25.5 cm @1.2X
Pixel Size100 μm @ 1.2X (DXA Mode), 31 μm @ 4X (DR Mode)
Operating SystemWindows 10, 64 bit (recommended)
Dimensions  (W x D x H)66 cm x 60.5 cm x 113 cm
Weight160 kg

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